Hotels in Defiance

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Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1004)
$89 nightly
The price is $105
Aug 24 - Aug 25
Total with taxes and fees
Sleep Inn & Suites O'Fallon MO - Technology Drive

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (587)
$129 nightly
The price is $147
Aug 24 - Aug 25
Total with taxes and fees
Best Western Plus Washington Hotel

Super 8 by Wyndham Union

2.0 star property
8.2 out of 10, Very Good, (610)
$80 nightly
The price is $88
Sep 1 - Sep 2
Total with taxes and fees
Super 8 by Wyndham Union

LAKEVIEWINN

2.5 star property
5.8 out of 10, (22)
$84 nightly
The price is $95
Aug 25 - Aug 26
Total with taxes and fees
LAKEVIEWINN

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (766)
$105 nightly
The price is $124
Aug 27 - Aug 28
Total with taxes and fees
Holiday Inn Express St. Louis West - O'Fallon by IHG

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very Good, (667)
$86 nightly
The price is $98
Sep 1 - Sep 2
Total with taxes and fees
Super 8 by Wyndham Washington

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1558)
$92 nightly
The price is $111
Sep 2 - Sep 3
Total with taxes and fees
The Wildwood Hotel

Hampton Inn & Suites St. Louis/Chesterfield

3.5 star property
8.8 out of 10, Excellent, (806)
$101 nightly
The price is $118
Aug 31 - Sep 1
Total with taxes and fees
Hampton Inn & Suites St. Louis/Chesterfield

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

2.5 star property
9.0 out of 10, Wonderful, (949)
$123 nightly
The price is $143
Aug 31 - Sep 1
Total with taxes and fees
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Super 8 by Wyndham St. Clair MO

2.0 star property
7.2 out of 10, Good, (895)
$74 nightly
The price is $81
Aug 24 - Aug 25
Total with taxes and fees
Super 8 by Wyndham St. Clair MO

Economy Inn Wentzville

2.0 star property
6.4 out of 10, (451)
$68 nightly
The price is $78
Aug 24 - Aug 25
Total with taxes and fees
Economy Inn Wentzville

Drury Inn & Suites Southwest St. Louis

3.0 star property
9.4 out of 10, Exceptional, (1003)
$115 nightly
The price is $135
Aug 31 - Sep 1
Total with taxes and fees
Drury Inn & Suites Southwest St. Louis

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 star property
9.4 out of 10, Exceptional, (1007)
$110 nightly
The price is $126
Aug 31 - Sep 1
Total with taxes and fees
Country Inn & Suites by Radisson, St. Charles Historic District

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.4 out of 10, Very Good, (1002)
$89 nightly
The price is $103
Aug 31 - Sep 1
Total with taxes and fees
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (990)
$104 nightly
The price is $118
Aug 24 - Aug 25
Total with taxes and fees
Baymont by Wyndham Warrenton

Courtyard by Marriott St. Louis Chesterfield

3.0 star property
9.0 out of 10, Wonderful, (547)
$115 nightly
The price is $134
Aug 31 - Sep 1
Total with taxes and fees
Courtyard by Marriott St. Louis Chesterfield

Quality Inn

2.5 star property
8.2 out of 10, Very Good, (837)
$95 nightly
The price is $108
Sep 22 - Sep 23
Total with taxes and fees
Quality Inn

Comfort Suites St Charles - St Louis

2.5 star property
8.4 out of 10, Very Good, (1006)
$100 nightly
The price is $115
Aug 31 - Sep 1
Total with taxes and fees
Comfort Suites St Charles - St Louis

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1000)
$86 nightly
The price is $101
Sep 1 - Sep 2
Total with taxes and fees
Comfort Inn & Suites St. Louis - O'Fallon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Defiance

Learn more about Defiance

Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

Check out reviews of Defiance hotels guests love

Frequently asked questions

How much does a hotel room cost in Defiance?
You can discover great hotels in Defiance from $78 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Defiance that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com. If you're a member, don't forget to sign in to your account to unlock more savings.
How can I find deals and earn rewards at Defiance hotels?
Members can save up to 20% on select hotels in Defiance. Plus, Silver, Gold and Platinum members earn extra rewards on VIP Access bookings, making each stay even more rewarding.

Can I book Defiance hotels with free cancellation?
To book a refundable Defiance hotel on Hotels.com, just filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are the top Defiance hotels with a pool?
To find more stays in Defiance with a pool, use the "Amenities" filter on Hotels.com in your search and select "Pool".
Are all taxes and fees included in the Defiance hotel prices shown on Hotels.com?
Hotels.com provides upfront pricing so you can relax knowing you won't be met with surprise additional fees or taxes when you're ready to confirm your booking. From the time you start your search on Hotels.com, the price you see is what you pay. This makes it much easier to compare properties and secure our best deal for your next getaway.
What hotels do travelers recommend in Defiance?
Guests like The Wildwood Hotel.
Can I book refundable accommodations in Defiance?
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Defiance

Find out more about Defiance

If you're looking to discover somewhere new, look no further than Defiance. Whether you're planning to stay for a night or for the week, the area around Defiance has accommodations to fit every need. Search for hotels in Defiance with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Defiance hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Defiance hotel deals are here with our lowest price guarantee.