Hotels in Mesopotamia

Free cancellation options if plans change

Unlock travel rewards with One Key

Save more with Member Prices

Check prices for these dates

Where to stay in Mesopotamia?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Mesopotamia

Showing deals for:Oct 24 - Oct 26

Check out hotels with a spa in Mesopotamia

You can also stay at hotels with a pool in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Mesopotamia

Learn more about Mesopotamia

Notable for its natural beauty, Mesopotamia features attractions such as Termas de Chajarí and Termas Federacion Water Park. This romantic city has something for everyone including sights like Termas de Federacion and Concordia Speedway.

Mesopotamia showing a river or creek and forest scenes

Check out reviews of Mesopotamia hotels guests love

Frequently asked questions

Why should I book my Mesopotamia hotel through Hotels.com?
There are lots of reasons to book your Mesopotamia trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Mesopotamia

Mesopotamia: Where Waterfalls Whisper Secrets of an Ancient Jungle

Mesopotamia, Argentina, is a hidden gem where lush jungles meet breathtaking waterfalls, creating a paradise for nature lovers and adventure seekers. Nestled between the Paraná and Uruguay rivers, this enchanting region boasts the stunning Iguazu Falls, a UNESCO World Heritage site, and the serene landscapes of the Misiones rainforest. Visitors can explore vibrant wildlife, embark on thrilling hikes, and immerse themselves in the rich Guarani culture. With its off-the-beaten-path allure, Mesopotamia offers a unique blend of natural wonder and cultural richness, making it an unforgettable destination for those seeking both adventure and tranquility.

Discover great hotels near Mesopotamia

In Mesopotamia, Argentina, you'll find a range of accommodations from cozy guest rooms to comfortable hotels. Options vary from budget-friendly places to more upscale stays, ensuring a pleasant experience for all travelers. Enjoy local hospitality while exploring the beautiful landscapes of the region. Here are some of the most popular hotels with our travelers near Mesopotamia:

  1. El Tránsito Hotel BoutiqueOpens in a new window: This charming 3.5-star hotel offers a delightful retreat for leisure travelers seeking a family-friendly atmosphere. With a focus on comfort and unique experiences, this property features amenities like a children’s pool and an engaging arcade game room, making it a perfect choice for families. The hotel provides complimentary cribs, ensuring a hassle-free stay for families with infants. Guests appreciate the welcoming ambiance and thoughtful facilities designed to enhance their vacation experience, creating lasting memories in a relaxing environment.

Things to do near Mesopotamia

Mesopotamia offers a stunning blend of lush forests, serene lakes, and rugged mountains, inviting travelers to explore its diverse landscapes. Enjoy birdwatching in vibrant wetlands, hike through scenic trails, or unwind by tranquil rivers. Whether you're seeking wildlife encounters or peaceful retreats, this region promises unforgettable experiences in nature.

  • Portal CarambolaOpens in a new window – Step into the lush paradise of Portal Carambola, a national State Park that immerses you in breathtaking waterfalls and vibrant jungle landscapes. Hike along the scenic trails where you can reconnect with nature and discover the rich biodiversity of the forests. Don’t forget your camera; the sights are perfect for capturing stunning photos of this natural wonder!
  • Col. C. Pelegrini SquareOpens in a new window – Take a leisurely stroll through Col. C. Pelegrini Square, a charming piazza that serves as a gathering spot for locals and visitors alike. Enjoy the serene atmosphere surrounded by lush greenery, and perhaps find a cozy café to sip on a refreshing drink while people-watching. The square is an ideal place to soak in the local vibe and relax amidst nature.
  • Carlos Pellegrini MarinaOpens in a new window – Head over to Carlos Pellegrini Marina, a picturesque marina where you can enjoy a variety of water activities. Whether you want to rent a boat for a leisurely ride or simply relax by the water’s edge, this marina is a great spot to unwind. The views of the surrounding nature and the gentle sounds of the water create a perfect escape from the hustle and bustle.

5 tips for savvy savings when booking a hotel near Mesopotamia

  1. Book for the cheapest times: The most affordable times to visit Mesopotamia are in April, September, and November when hotel prices tend to be lower. For those on a budget, a stay of at least 2 to 3 days is perfect for discovering the area's notable landmarks, rich history, and cultural attractions. Visitors can enjoy breathtaking waterfalls, lush forests, and opportunities for hiking and birdwatching, all of which provide great value for money. By choosing these months, you might find that prices may drop, allowing for a memorable yet budget-friendly experience.
  2. Look for last-minute deals on Hotels.com: To uncover last-minute deals to Mesopotamia, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window sections on Hotels.com, where you may discover discounted hotel rates as your travel date approaches. By enabling email alerts or push notifications, you could find out about flash sales and special promotions, ensuring you stay informed about potential savings. Additionally, the Smart ShoppingOpens in a new window tool available via the app allows you to compare hotel prices and amenities, giving you the best chance to secure the ideal room at a competitive rate. If prices drop or rooms become available, you'll be among the first to know, making your last-minute getaway easier.
  3. Be flexible with dates: Prices can fluctuate based on factors like the hotel's location, star rating, and the time of year, so being flexible with your travel dates may help you save on your stay near the Mesopotamia hotel. For those seeking unique accommodations, boutique hotels often provide a more personalized experience and can sometimes offer better value. When you book through Hotels.com, we’ll inform you if the price for your chosen dates is above or below the average. If the price is on the higher side, we’ll recommend more budget-friendly dates that could help you secure a better deal.
  4. Consider your location: Staying near major attractions or city centers can be convenient, but it usually tends to be more expensive. For more budget-friendly options, think about hotels in less central areas or neighborhoods that strike a balance between cost and accessibility to the sites you want to visit. You might also look into independent hotels located further away, as they can offer a more authentic and affordable experience.
  5. Become a Member: Join our membership program for free and unlock incredible savings on your next stay near Mesopotamia! With access to over 100,000 hotels worldwide, you can take advantage of exclusive member prices that make your travel more affordable.As a member, you’ll have the opportunity to advance through the tiers, enjoying fantastic perks such as complimentary room upgrades when available and discounts on food and beverages at select VIP Access properties. Don’t miss out on the chance to enhance your travel experience—sign up today and start saving!